The attack was a popular shrine of a Sufi saint, Sakhi Sarwar, Dera Ghazi Khan, a district far away from the Province of Punjab, said the police officials. An annual festival was underway, as hundreds of faithful inhabited the shrine compound when attackers detonate their explosives.
Police officers said that the attackers did not enter the Sanctuary because of strict security measures.
With the wounded in critical condition, representatives of the rescue said that the number of deaths has been expected to increase.
A third attacker, who was injured, was arrested after the failure of his jacket laden with explosives to bomb everything. The man appeared to be tribal regions near the Afghan border, police said.
The wounded were taken to the hospital. Emergency workers said that they have been facing difficulties in rescue operation.
Tehreek-e-Taliban Pakistan, or the Taliban, a group of activists coordinated movement, claimed responsibility for the attack, Reuters reported.
Activists Taliban have repeatedly to attacks across the country Sufi shrines, with Government targets and security forces facilities.
The attack Sunday was seen as another attempt by militants to exacerbate the ideological divisions that exist in different schools of Sunni Islam.
Deobandis are a puritanical branch of Sunni Islam, to which belong the most militant of the country groups. The Barelvi sect followers, on the other hand believe in mysticism, venerate saints and shrines and are considered to be tolerant and accommodating other confessions.
Although there is no accurate statistics, estimated that more than 75 per cent of the population of Pakistan endorses the Barelvi School of thought, following many Sufi practices. Punjab province for more prosperous and the most populated of the country, has a majority of Barelvi. Hard Deobandis consider heretical Barelvis.
Barelvi religious leaders have described the attacks as an attempt to sow sectarian strife.
"It is an act of terrorism by the Taliban," said Sahibzada Muhammad Fazal Kareem, a member of Parliament and leader of the Ittihad Sunni Council, an alliance of eight religious parties opposed to the Taliban.
"They want to destroy the peace of the country and attacks on shrines are a heinous plot to raise sectarian tensions and riots," said Mr. Kareem.
He criticized the Government for failing to provide adequate shrines security.
The shrine of Sakhi Sarwar, a saint of the 12th century, is 25 km from the capital of the district in the southern part of the Province of Punjab. Activists issuing threats against the shrine, said police officials.
Dera Ghazi Khan bordering the Province of Khyber Pakhtunkhwa Northwest and the Province of Balochistan and is known as the gateway of Punjab.
Recently, it has concerns that militants of the tribal areas of the Province of Khyber Pakhtunkhwa, formerly Frontier Northwest Province, have been using Dera Ghazi Khan as a route to enter the Punjab.
Concerns about increasing militancy and extremism have also emerged in recent years in southern Punjab, where feudal influence is strong and the majority of the population is poor and uneducated. The area also abounds with madrassas, seminars or religious.
Prime Minister Yousaf Raza Gilani condemned the attack.
"These cowardly acts of terror clearly demonstrate that the culprits involved have any faith or any belief in human values," said a statement by the Prime Minister's Office.
Salman Masood reported to Islamabad and Waqar Gillani in Lahore, Pakistan.
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